Synthetic Route of 776-53-4, Adding some certain compound to certain chemical reactions, such as: 776-53-4, name is Ethyl 4-amino-2-(methylthio)pyrimidin-5-carboxylate,molecular formula is C8H11N3O2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 776-53-4.
1.2.2 Synthesis of Compound 2 4.12 g (19.3 mmol) of Compound 1 was dissolved in 15 mL of methanol.3 mL of a 0.50 g / mL lithium hydroxide aqueous solution was added dropwise to the reaction solution, and the reaction was performed at 50 C for 5 hours.After the reaction is completed, 30 mL of a saturated ammonium chloride solution is added to the reaction solution to quench the reaction, and the mixture is extracted with ethyl acetate (20 mL ¡Á 3).The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The residue was separated and purified by column (PE / EA, 1: 3) to obtain 3.25 g of a white solid with a yield of 91.0 %
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 776-53-4, Ethyl 4-amino-2-(methylthio)pyrimidin-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Mudanjiang Normal College; Jing Yunrong; Wei Jicheng; Hao Jingwei; (15 pag.)CN110256445; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia