In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 814918-95-1, name is 5-Bromo-4-chlorothieno[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. Application In Synthesis of 5-Bromo-4-chlorothieno[2,3-d]pyrimidine
i) 5-bromo-4-[4-(2-pyrrolidin- 1 -ylethoxymethyl)- 1 -piperidyl]thieno[2,3-d]pyrimidine5-Bromo-4-chlorothieno[2,3-d]pyrimidine (828 mg 3.33 mmol) in dry acetonitrile (13 mL) was treated with 4-(2-pyrrolidin- 1 -ylethoxymethyl)piperidine (1.057 g, 5.0 mmol,) and potassium carbonate (687 mg, 5.0 mmol) and heated at 110 C for 30 min in a microwave. The reaction was then poured into ethyl acetate (50 mL) and water (30 mL) and the ethyl acetate layer separated, dried over sodium sulphate and concentrated in vacuum to give 5- bromo-4-[4-(2-pyrrolidin-l -ylethoxymethyl)- l-piperidyl]thieno[2,3-d]pyrimidine (1.322 g, 3.11 mmol, 93%). LCMS RT = 2.91 min. M+l = 427.
The synthetic route of 814918-95-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; XENTION LIMITED; MADGE, David; CHAN, Fiona; JOHN, Derek Edward; EDWARDS, Simon D.; BLUNT, Richard; HARTZOULAKIS, Basil; BROWN, Lindsay; WO2013/72694; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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