Adding a certain compound to certain chemical reactions, such as: 55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
General Procedure 1.1 Preparation of 4-alkylamino-6-chloro-2,5-diamine-pyrimidine A suspension of 4,6-dichloro-pyrimidine-2,5-diamine (31.4 mmol), diisopropylethylamine (175 mmol), and R5R4-NH2 (29.5 mmol) in n-BuOH (300 ml), was heated to 115 C. for 6 hours. After removal of the solvent, EtOAc was added to the residue, and it washed with water, brine and dried with Na2SO4 and purified by flash chromatography to give the 4-Alkylamino-6-chloro-2,5-diamine-pyrimidine.; Example 1 6-chloro-N4-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)pyridine-2,4,5-triamine The title compound was prepared by condensation between 4,6-dichloro-pyrimidine-2,5-diamine and 2-aminomethyl-3,5-dimethyl-4-methoxy-pyridine according to the general procedure 1.1 HPLC 3.52 min. 1H-NMR (CDCl3): delta 8.24 (s, 1H), 7.12 (br s, 1H), 4.61 (s, 2H), 4.555 (d, 2H), 3.80 (s, 3H), 3.0 (s, 2H), 2.29 (s, 3H), 2.27 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,55583-59-0, 2,5-Diamino-4,6-dichloropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; CONFORMA THERAPEUTICS CORPORATION; US2007/253896; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia