With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride, molecular formula is C6H9ClN2O, molecular weight is 160.6015, as common compound, the synthetic route is as follows.COA of Formula: C6H9ClN2O
Add 0.160 g (1 mmol) of 2-hydroxy-4,6-dimethylpyrimidine hydrochloride to a 100 mL eggplant-shaped bottle,0.408 g (3 mmol) of 4-methoxybenzaldehyde and 0.1 mL (1.2 mmol) of concentrated hydrochloric acid,Add absolute ethanol (40 mL) to dissolve the reaction.Heat to reflux at 80 C for 24h.After the reaction is completed, the solvent is distilled off under reduced pressure.Add a saturated aqueous sodium bicarbonate solution and stir well to precipitate a solid.The crude product was washed three times with water and dried, and then separated and purified by column chromatography (methanol: dichloromethane = 1:10).0.252 g of 2-hydroxy-4,6-bis (4-methoxystyryl) pyrimidine is obtained,The yield was 70%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,34289-60-6, 4,6-Dimethylpyrimidin-2-ol hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; Ocean University of China; Jiang Tao; Zhang Lijuan; Tong Sheng; Zhang Meng; (30 pag.)CN105198820; (2019); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia