Adding a certain compound to certain chemical reactions, such as: 633328-95-7, 5-Bromo-2-chloro-4-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
Step 1: DIPEA (804 pL, 4.70 mmol) was added to 5-bromo-2-chloro-4- methylpyrimidine (650 mg, 3.13 mmol) dissolved in CH3CN (20 mL). Then, thiomorpholine-1 ,1-dioxide (508 mg, 3.76 mmol) was added to the mixture. The mixture reaction was heated at 75C for 48h. Solvent was removed under reduced pressure. H20 and AcOEt were added to the residue. The organic layer was separated, dried over Mg504, filtered and the solution was concentrated to dryness to afford 4-(5-bromo-4-methylpyrimid in-2-yl)-1 – thiomorpholine-1 ,1-dione Ex.30a (732 mg, 76%) as yellow solid. The compound was used as such in the next step.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,633328-95-7, 5-Bromo-2-chloro-4-methylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; GENFIT; DELHOMEL, Jean-Francois; PERSPICACE, Enrico; MAJD, Zouher; PARROCHE, Peggy; WALCZAK, Robert; BONNET, Pascal; FOGHA, Jade; (144 pag.)WO2018/138359; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia