Related Products of 1142188-60-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1142188-60-0, name is tert-Butyl 4-hydroxy-5,6-dihydropyrido[3,4-d]pyrimidine-7(8H)-carboxylate, molecular formula is C12H17N3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
31-B. 4-Chloro-5,8-dihydro-6H-pyrido[3,4-]pyrimidine-7-carboxylic acid tert-buty ester.; Triphenylphosphine (17.3 g, 66.1 mmol) is added to a solution of 4-0x0-4,5, 6,8-tetrahydro-3H- pyrido[3,4-(/|pyrimidine-7-carboxylic acid tert-butyl ester (8.30 g, 33.0 mmol), CCl4 (9.6 mL, 99 mmol), and 1,2-dichloroethane (250 mL). The solution is heated at 70 0C for 2.5 h. The solution is concentrated in vacuo to about 50 mL. The contents of the flask are then filtered over a silica gel plug eluting with 60% EtO Ac/heptane. The residue following concentration is then further separated via flash chromatography (10-30% EtO Ac/heptane) to give the title compound.MS (ESI) m/z 270.0 & 272.0 (M+l); 1H NMR (400 MHz, CDCl3) delta ppm 8.79 (s, 1 H), 4.65 (s, 2 H), 3.74 (t, J=5.8 Hz, 2 H), 2.87 (t, J=5.8 Hz, 2 H), 1.49 (s, 9 H).
According to the analysis of related databases, 1142188-60-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NOVARTIS AG; ARTMAN III, Gerald David; ELLIOTT, Jason Matthew; JI, Nan; LIU, Donglei; MA, Fupeng; MAINOLFI, Nello; MEREDITH, Erik; MIRANDA, Karl; POWERS, James J.; RAO, Chang; WO2010/66684; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
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