As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33097-11-9, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carbaldehyde, molecular formula is C6H4Cl2N2OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H4Cl2N2OS
After the compound obtained in Step 1 was dissolved in dichloromethane,N, N’-diisopropylamine was added at room temperature, and the reaction mixture was cooled to 0 C and 4,6-dichloro-2- (methylthio) pyrimidine-5-carbaldehyde was added, And stirred for 2 hours.The reaction mixture was extracted with dichloromethane and water.The organic layer was dried over magnesium sulfate and then distilled under reduced pressure.The resulting residue was purified by MPLC to obtain the title compound.
With the rapid development of chemical substances, we look forward to future research findings about 33097-11-9.
Reference:
Patent; Hanrim Pharmaceutical Co., Ltd.; Kim Gyeong-hui; Jin Jeong-uk; Lee Ji-hun; Kim Sin-ae; Jeong Gyeong-jin; Kim Jun-u; Min Sang-hyeon; Ryu Ji-hun; Lee Ju-seok; Lee Won-seok; Song Jae-yeong; Lee Eung-seok; Jeong Tae-cheon; Kim Jeong-ae; (35 pag.)KR2019/73673; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia