Application of 397308-78-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.397308-78-0, name is 4-Hydroxy-2-(methylthio)pyrimidine-5-carboxylic acid, molecular formula is C6H6N2O3S, molecular weight is 186.19, as common compound, the synthetic route is as follows.
In a 250mL round bottom flask with magnetic stir bar, 4-hydroxy-2- (methylsulfanyl)pyrimidine-5-carboxylic acid (12 g, 64.45 mmol, 1.00 eq.) was suspended in thionyl chloride (120 mL). The resulting solution was stirred for 18 h at 80 C, and then concentrated under reduced pressure to afford the acid chloride intermediate.
The chemical industry reduces the impact on the environment during synthesis 397308-78-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK PATENT GMBH; QIU, Hui; CALDWELL, Richard D.; NEAGU, Constantin; MOCHALKIN, Igor; LIU-BUJALSKI, Lesley; JONES, Reinaldo; TATE, Devon; JOHNSON, Theresa L.; GARDBERG, Anna; WO2015/61247; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
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