In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4433-40-3, name is 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione, the common compound, a new synthetic route is introduced below. Quality Control of 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione
To a suspension of 5-(hydroxymethyl)pyrimidine-2,4(1H,3H)-dione (35.0 g, 246.3 mmol) in toluene (100 mL) was added POCl3 (105 mL, 1147 mmol) followed by slow addition of DIPEA (120 mL, 689 mmol), the mixture was tirred at 110-120 oC for 8 h. Then the reaction mixture was poured to a mixture of water (100 mL) and ethyl acetate (200 mL), extracted with ethyl acetate (1 L ¡Á 2), washed with brine (200 mL ¡Á 3), died with Na2SO4. Purified by silica gel (DCM) to give 2,4-dichloro-5- (chloromethyl)pyrimidine as light yellow solid (22 g), yield 46percent. LC/MS (ESI) m/z = 197 (M + H) +.
The synthetic route of 4433-40-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; GRAY, Nathanael, S.; LIANG, Yanke; CHOI, Hwan, Geun; SUNDBERG, Thomas; SHAMJI, Alykhan; XAVIER, Ramnik; FISHER, David E.; (251 pag.)WO2018/9544; (2018); A1;,
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