Reference of 583878-42-6, Adding some certain compound to certain chemical reactions, such as: 583878-42-6, name is Ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate,molecular formula is C9H11ClN2O2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 583878-42-6.
To a solution of Intermediate III-A1 (400 mg, 1 mmol) dissolved in MeOH (4 mL) was added conc. HCl (4 mL) . The resulting mixture was concentrated at 50 to dryness. The residue was dissolved in n-BuOH (20 mL) , and then added DIEA (1 mL) and ethyl 4-chloro-6-methyl-2- (methylthio) pyrimidine-5-carboxylate (246 mg, 1 mmol) . The mixture was stirred at rt. for 2h, and then concentrated to remove the solvent. The residue was purified by flash column chromatography to afford the title compound as a solid (500 mg) . Yield: 97.8. MS (ESI) : calcd. value for C24H23ClN6O3S is 510.12, m/z measured value is 511.1 (M+1)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 583878-42-6, Ethyl 4-chloro-6-methyl-2-(methylthio)pyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DAI, Guangxiu; JIA, Hong; ZHANG, Zhulin; WENG, Jianyang; VENABLE, Jennifer Diane; BEMBENEK, Scott Damian; CHAI, Wenying; MEDUNA, Steven Paul; KEITH, John Matthew; ECCLES, Wendy; LEBSACK, Alec Donald; JONES, William Moore; SMITH, Russell Christopher; (195 pag.)WO2016/119707; (2016); A1;,
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