Adding a certain compound to certain chemical reactions, such as: 60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H3ClN4, blongs to pyrimidines compound. Computed Properties of C5H3ClN4
e) (S)-4-Amino-6-(2-(5-(methylsulfonyl)-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yI)pyrrolidin-1 -yI)pyrimidine-5-carbonitrileA solution of (S)-5-(methylsu lfonyl)-3-phenyl-2-(pyrrolid in-2-yl)quinazolin-4(3H)-one (38 mg,0.10 mmol) and 4-amino-6-chloropyrimidine-5-carbonitrile (CAS registry 60025-09-4) (15.9mg, 0.10 mmol) in EtCH (1 ml) was treated with DIPEA (0.045 ml, 0.26 mmol) and wasstirred at 120C for 45 mm in mw. The reaction mixture was evaporated under reducedpressure. The oil was taken up in DCM and washed with sat. aq. NHCO3soln., the organic layer was dried over Na2SO4 and concentrated in vacuo. The crude was purified over SFC (column PPU, 250 x30 mm, 60A, 5pm, Princeton, flow at 100 mI/mm; gradient of MeCH in supercritical CC2, from 18 % to 23 % in ii mm) to afford the title compound as a beige solid(33 mg, 63 % yield).HPLC RtM2=0.87 mm; ESIMS: 488 [(M+H)].1H NMR (400 MHz, DMSC-d6): O 8.24 (dd, 1 H), 7.85-8.05 (m, 3 H), 7.50-7.70 (m, 5 H),7.24 (br s, 2 H), 4.50 – 4.75 (m, 1 H), 3.99 – 4.16 (m, 1 H), 3.80 – 3.97 (m, 1 H), 3.48 (5, 3 H),2.18 -2.31 (m, 1 H), 2.05 -2.18 (m, 1 H), 1.78- 2.03 (m, 2 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,60025-09-4, 4-Amino-6-chloropyrimidine-5-carbonitrile, and friends who are interested can also refer to it.
Reference:
Patent; NOVARTIS AG; GUIBOURDENCHE, Christel; HINTERMANN, Samuel; HURTH, Konstanze; JACQUIER, Sebastien; KALIS, Christoph; MOEBITZ, Henrik; SOLDERMANN, Nicolas; WO2014/128612; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia