Synthetic Route of 28732-79-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 28732-79-8, name is 4-Chloropyrido[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.
Intermediate 20 (400 mg, 0.89 mmol) was dissolved in DCM (23 mL) and TFA (4.1 mL) was added. The mixture was stirred at r.t. for 1.5 h and excess DCM and TFA were removed in vacuo. The yellow residue obtained was basified using 0.2M aqueous NaOH (40 mL) and extracted with EtOAc (3 x 80 mL). The combined organic layers were dried (MgS04) and concentrated in vacuo. Purification by column chromatography on silica, eluting with DCM/MeOH/NH3 (95:4:1), gave a colourless gum (278 mg, 90%). deltaEta (CDC13) 7.94 (IH, s), 7.52 (IH, dd, J 8.8, 6.1 Hz), 7.15 (IH, t, J 8.9 Hz), 5.11 (IH, br s), 4.98 (IH, br s), 3.80-3.76 (2H, m), 3.75 (3H, s), 3.70-3.59 (2H, m), 3.56-3.42 (2H, m), 3.21-3.07 (2H, m), 2.59 (3H, d, J 2.40 Hz), 1.54 (3H, s). LCMS (ES+) 347 (M+H)+. A solution of this gum (55.6 mg, 0.161 mmol), 4-chloropyrido[2,3-i?pyrimidine (40 mg, 0.24 mmol) and DIPEA (0.084 mL, 0.48 mmol) in ?-butanol (1 mL) was heated to 130C under microwave irradiation for 1 h. Purification by preparative HPLC afforded the title compound (41 mg, 54%) as a white solid. deltaEta (DMSO-Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MATTEUCCI, Mizio; OWENS, Andrew, Pate; RAPHY, Gilles; SHARPE, Andrew; WO2011/58108; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia