Synthetic Route of 1500-85-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1500-85-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, molecular formula is C6H6N4, molecular weight is 134.14, as common compound, the synthetic route is as follows.
To a solution of 200 mg (1.49 mmol) of 7H-pyrrolo[2,3-d]pyrimidin-4-amine in 4 mL of DMF, 235 muL of dimethylformamide dimethyl acetal were added. The mixture was stirred at room temperature overnight. The solvent was then removed in vacuo and the residue taken up with DCM, washed with brine, dried over anhydrous Na2SO4and evaporated to dryness. The crude was triturated with diisopropylether and filtered, to afford 204 mg (73%) of the title compound. 1H NMR (600 MHz, DMSO-cie) delta ppm 3.10 (s, 3 H) 3.16 (s, 3 H) 6.45 (dd, J=3.39, 1.92 Hz, 1 H) 7.21 (dd, J=3.11 , 2.38 Hz, 1 H) 8.28 (s, 1 H) 8.79 (s, 1 H) 11.60 (br. s., 1 H) HRMS (ESI) calcd for C9HnN5 [M+H]+ 190.1087, found 190.1085.
The chemical industry reduces the impact on the environment during synthesis 1500-85-2, I believe this compound will play a more active role in future production and life.
Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; ANGIOLINI, Mauro; BUFFA, Laura; MENICHINCHERI, Maria; MOTTO, Ilaria; POLUCCI, Paolo; TRAQUANDI, Gabriella; ZUCCOTTO, Fabio; WO2014/184069; (2014); A1;,
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