Electric Literature of 1004-39-3, Adding some certain compound to certain chemical reactions, such as: 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol,molecular formula is C4H6N4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1004-39-3.
General procedure: DBU (0.5 mmol, 0.08 g) was added dropwise at room temperature to a magnetically stirred suspension of appropriate thiol 2 (0.5 mmol) in 1 ml of MeCN. The mixture was stirred for 10 min and then appropriate nitrofuroxan 1 (0.5 mmol) was added. The mixture was stirred for 0.5-10 h until initial compound 1 disappeared (TLC monitoring, eluent – CHCl3). Next, H2O (7 ml) was added and the reaction mixture was acidified with 1 n HCl until pH 1. The produced solid was filtered off, washed with water and the MeCN minimal volume (~1 ml), and air-dried. Compounds 3i and 4 were prepared as a mixture. The mixture was treated with 2 ml of DMSO at 60 C for 30 min; the undissolved solid was filtered off, water-washed and air-dried to afford disulfide 4. The filtrate was diluted with water and the solid was filtered off, water-washed and air-dried to afford compound 3i.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1004-39-3, 4,6-Diaminopyrimidine-2-thiol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fershtat, Leonid L.; Epishina, Margarita A.; Kulikov, Alexander S.; Makhova, Nina N.; Mendeleev Communications; vol. 25; 1; (2015); p. 36 – 38;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia