Related Products of 287714-35-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate, molecular formula is C6H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation 79: 2-[(3i?,45)-3-feri-Butoxycarbonylamino-4-(2,5-difluoro-phenyl)- pyrrolidin-l-yl]-pyrimidine-5-carbox lic acid methyl esterTo a solution of 2-chloro-pyrimidine-5-carboxylic acid methyl ester (2.1 g, 12mmol) and [(3R,45′)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester (Preparation 193, 4.0g, 13mmol) in DCE (l OOmL) was added triethylamine (3.3mL, 23mmol) and the resulting reaction mixture was stirred at r.t. for 16 h. The reaction mixture was diluted with DCM (200mL), washed with water (200mL) and brine (400mL), dried (MgS04), filtered and concentrated in vacuo. The remainder was triturated with MeOH and the solid collected by filtration to afford the title compound: RT = 3.95 min; mlz (ES ) = 435.18 [M+ H]+.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 287714-35-6, Methyl 2-chloropyrimidine-5-carboxylate.
Reference:
Patent; PROSIDION LIMITED; BARBA, Oscar; BERTRAM, Lisa, Sarah; CARSWELL, Emma Louise; DAVIS, Susan, Helen; FRY, Peter, Timothy; GLEAVE, Robert James; JEEVARATNAM, Revathy, Perpetua; JOHNSTONE, Craig; KEILY, John; PROCTER, Martin, James; SCHOFIELD, Karen, Lesley; STEWART, Alan, John, William; SWAIN, Simon, Andrew; WO2013/26587; (2013); A1;,
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