A new synthetic route of 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1100318-96-4, 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1100318-96-4, 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, blongs to pyrimidines compound. Safety of 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine

Dry DMFWas added K2CO3 to a solution of 4-iodo-7h-pyrrolo [2,3-d] pyrimidine (4) and the mixture was stirred at room temperature for 30 minutes. After 30 minutes, 2- (trimethylsilyl) ethoxymethyl chloride was added dropwise to the solution,The reaction was stirred for 6 hours. For quenching, a saturated aqueous NH4Cl solution was added to the solution. The mixture was poured into ethyl acetate and extracted twice with ethyl acetate. The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography (hexane / ethyl acetate) to give the desired compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1100318-96-4, 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Gwangju Institute of Science and Technology; INDUSTRY-ACADEMIC COOPERATION FOUNDATION GYEONGSANG NATIONAL UNIVERSITY; Kim, Yong-Chul; Han, Son-Young; Ko, Hyo-Jin; Lee, Son-Mi; (28 pag.)KR2016/124034; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia