Sources of common compounds: Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36822-08-9, Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36822-08-9, name is Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one, molecular formula is C10H6N2OS, molecular weight is 202.2324, as common compound, the synthetic route is as follows.Safety of Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one

Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one (10.78 g, 26.7 mmol) was treated with pyridine (2.68 mL, 33.3 mmol) and phosphoryl trichloride (53.4 mL, 573 mmol), then heated to reflux at 110 C. for 1 hr. Excess POC3was removed and cautiously quenched with ice water in an ice bath. The pH was adjusted to 5 with ammonium hydroxide. Solid was collected by filtration washed with water. The solid was dried to give 4-chlorobenzo[4,5]thieno[3,2-d]pyrimidine (10 g, 85% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36822-08-9, Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; Universal Display Corporation; Joseph, Scott; Kwang, Raymond; Lee, Chi Hang; Shia, Chuan Jun; Ram, SiV Cheung; (131 pag.)KR2015/9461; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia