Application of 25940-35-6, Adding some certain compound to certain chemical reactions, such as: 25940-35-6, name is Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid,molecular formula is C7H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25940-35-6.
PyBOP (298 mg, 572 pmol) was added to a mixture of 8-amino-3-(2-chlorophenyl)-1,3- diazaspiro[4.5]decane-2,4-dione (mixture of cis-/trans-isomers) (140 mg, 477 pmol, Intermediate 36), pyrazolo[1 ,5-a]pyrimidine-3-carboxylic acid (97.2 mg, 596 pmol) and N,Ndiisopropylethylamine (420 p1, 2.4 mmol) in DMF (1.7 ml) and the mixture was stirred overnight at room temperature. For work-up, water was added and the mixture was extracted with ethyl acetate. The combined organic phases were filtered through a silicone filter and concentrated. The residue was purified by preparative HPLC to give the title compound 45.0 mg (21 % yield).[C-MS (Method 2): R = 0.88 mm; MS (ESIneg): m/z = 437 [M-H]1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 9.34-9.31 (m, 1H), 8.93 (5, 1H), 8.82 (dd, 1H), 8.59 (5, 1H), 8.11 (d, 1H), 7.68-7.64 (m, 1H), 7.56-7.45 (m, 3H), 7.29-7.25 (m, 1H), 4.14-4.04 (m, 1 H), 2.23-1.67 (m, 8H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25940-35-6, Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; WAGNER, Sarah; SUeLZLE, Detlev; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; (232 pag.)WO2018/78009; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia