Related Products of 13036-50-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13036-50-5, name is 2-Chloro-4-phenylpyrimidine, molecular formula is C10H7ClN2, molecular weight is 190.629, as common compound, the synthetic route is as follows.
Example 37 2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetamidePart I: 2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetic acidGeneral Procedure I: Microwave assisted halogen displacement with amino group [0166] A mixture of 2-chloro-4-phenylpyrimidine (0.19 g, 1.0 mmol), 2-(4- aminophenyl)acetic acid (0.38 g, 2.5 mmol), diisopropylethylamine (0.38 mL, 2.0 mmol), THF (3.0 mL) and water (1.0 mL) was placed in a seal tube and heated up to 160C in a microwave (Biotage, Model: Initiator) for 1O h. The reaction mixture was diluted with ether and washed with brine. The organic layer was separated, dried (MgSO4), and concentrated to afford 2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetic acid in 77% yield. MS (ESI) 306 (M+H).
Statistics shows that 13036-50-5 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-phenylpyrimidine.
Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/32861; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia