Reference of 52606-02-7 ,Some common heterocyclic compound, 52606-02-7, molecular formula is C7H8N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 10 rac-5-[(4S*,5R*)-4,5-Bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1 H-imidazol-2-yl]-2,4-dimethoxy-pyhmidineThe title compound was prepared using the procedure described by Ishihara, M. and Togo, H. Synlett 2006, 2, 227-230 and ibid Tetrahedron 2007, 63, 1474- 1480.Iodine (172 mg, 0.68 mg) was dissolved in tert-butanol (20 ml_) and potassium carbonate (300 mg, 2.2 mmol) was added. 2,4-Dimethoxy-5-formylpyhmidine (100 mg, 0.6 mmol, Frontier) and (rac)-2,3-Bis(4-chloro-phenyl)-butane-2,3- diamine (200 mg, 0.65 mmol) was added to the mixture. This was warmed to 65 0C for 2 h. This was cooled, diluted with ethyl ether (50 ml_) and filtered through CeI ite. After evaporating to dryness, the residue was purified by flash column chromatography (silica gel, eluting with 2-5% methanol/methylene chloride) to give rac-5-[(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5- dihydro-1 H-imidazol-2-yl]-2,4-dimethoxy-pyrimidine.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,52606-02-7, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/47161; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia