Related Products of 66131-68-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 66131-68-8, name is 2-Chloro-N-methylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.
A solution of 2-(5-chloro-2,4-dimethoxyphenyl)-7-(piperazin-1-yl)imidazo[1,2-a]pyridine 301 (200 mg, 0.53 mmol) and N,N-diisopropylethylamine (0.4 mL, 2.29 mmol) in DMF (5 mL) was charged with 2-chloro-N-methylpyrimidin-4-amine ( 155 mg, 1.07 mmol). The reaction mixture was stirred at 100 C for 16 h. The reaction mixture was cooled to room temperature, suspended in water and stirred for 1 h. The precipitate was collected by filtration; the solid obtained was washed with water, dried under reduced pressure and purified by combi-fash companion (silica gel, CH3OH/CH2Cl2). The product was further triturated with methanol and filtered. The solids were washed with hexanes and dried to provide 2-(4-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)piperazin-1-yl)-N-methylpyrimidin-4-amine 418a (20 mg, 8%) as light brown solid. 1H NMR (300 MHz, DMSO-d6) delta 8.34 i d . ./ 7.5 Hz, 1H), 8.15 (s, 1H), 8.04 (s, 1H), 7.75 (br s, 1H), 6.97 (br s, I I I ) . 6.89 (s, IH), 6,87 (s, 1H), 6,71 (s, i l l ). 5.78 (d, ./ 5,7 Hz, 1H), 4.01 (s, 3H), 3.93 (s, 3H), 3.83 (br s, 4H), 3.33 (br s, 4H), 2,78 (d, ,/ 4.2 Hz, 3H): HPLC (Method 1 ) 92.8% (AUC), fR = 1 1.85 min.; ESI+APCI MS m/z 480 [M + Hf.
According to the analysis of related databases, 66131-68-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; CHAKRABARTI, Anjan; RAWAT, Manish; RAI, Sanjay; SATYANARAYANA, Arvapalli, Venkata; DUAN, Zhiyong; TALUKDAR, Arindam; RAVULA, Srinivas; DECORNEZ, Helene; (491 pag.)WO2017/58503; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia