Application of 148550-51-0

Statistics shows that 148550-51-0 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate.

Reference of 148550-51-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.148550-51-0, name is Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate, molecular formula is C8H10N2O4S, molecular weight is 230.24, as common compound, the synthetic route is as follows.

A solution of (E)-2-chloro-l l-(piperazin-l-yl)dibenzo[b,f][l,4]oxazepine (0.25 g, 0.8 mmol) and ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate (0.13 g, 0.57 mmol) in DME was stirred at room temperature for 1 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with saturated aqueous solution of bicarbonate, water, acetic acid and sodium acetate (pH=4), dried over sodium sulfate and solvent evaporated. The resulting crude residue was purified by flash chromatography (0percent to 30percent ethyl acetate in hexane) to afford title compound 116 (0.265 g, quant.).

Statistics shows that 148550-51-0 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate.

Reference:
Patent; METHYGENE INC.; EN VIVO PHARMACEUTICALS, INC.; WO2008/55068; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia