Electric Literature of 1209459-32-4, Adding some certain compound to certain chemical reactions, such as: 1209459-32-4, name is 4-(2-Bromopyrimidin-4-yl)morpholine,molecular formula is C8H10BrN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1209459-32-4.
To a microwave tube was added N-isopropyl-3-(trimethylstannyl)-1-trityl-1H-pyrazolo[4,3-c]pyridin-4-amine (200 mg, 0.344 mmol), 4-(2-bromopyrimidin-4-yl)morpholine (168 mg, 0.688 mmol), LiCl (58.0 mg, 1.38 mmol), CuI (13.0 mg, 0.0688 mmol), Pd(PPh3)4 (40.0 mg, 0.0344 mmol), and THF (3.0 mL). After three cycles of vacuum/argon flash, the reaction mixture was heated at 100 C. for 1 hour under microwave irradiation. After cooling down to room temperature, the mixture was filtered via Celite. The filtrate was concentrated under reduced pressure. The residue was purified by prep-TLC eluting with petroleum ether/ethyl acetate (1:2) to afford the title compound as a yellow solid (25 mg, 13%).
According to the analysis of related databases, 1209459-32-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Genentech, Inc.; Chan, Bryan; Estrada, Anthony; Shore, Daniel; Sweeney, Zachary; US2014/288043; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia