Reference of 287714-35-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate, molecular formula is C6H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-(N-Boc-amino)piperidine 9.3 g was added to a 250 mL three-necked flask.N,N-dimethylacetamide 100mL,N,N-diisopropylethylamine 7.5 g,2-chloropyrimidine-5-carboxylic acid methyl ester 4.0 g,Stir at room temperature for 3 h under nitrogen.The end of the reaction was monitored by TLC (petroleum ether: ethyl acetate = 2:1).200 mL of water was added and extracted with dichloromethane (100 mL x 3), and the organic phases were combined.The organic phase was washed successively with 5% dilute hydrochloric acid (100 mL¡Á3) and saturated sodium chloride (100 mL¡Á3).The organic phase was dried over anhydrous sodium sulfate for 2 h, filtered, and evaporated, evaporated, evaporated.A white solid was obtained in 6.8 g, yield: 87.1%.
According to the analysis of related databases, 287714-35-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Medical Sciences Radioactive Medical Institute; Li Yiliang; Wei Huiqiang; Gao Jun; Bi Changfen; Ning Hongxin; Yu Jiang; Gou Wenfeng; Duan Yuqing; (35 pag.)CN109232541; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia