Related Products of 5604-46-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5604-46-6, name is 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde. A new synthetic method of this compound is introduced below.
The compound of formula () (2.4g, 12.5mmol) and 37.5mL THF was added 12.5mL H 2 O mixed solution Were heated to 50 C, was added hydrazine hydrate (1.5g, 25.2mmol), 50 C After stirring for 5min, stirred at room temperature for 20min, was added 100mL of ice water stirring 15min, after unscrew the THF was filtered and dried under vacuum to give a yellow solid 2.06 g, yield 97.6%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5604-46-6, 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde, and friends who are interested can also refer to it.
Reference:
Patent; Shanghai Jiao Tong University; Shen, YuMei; Wei, XiaoFei; Gong, Bing; Hu, Yu; Jiang, Yu; Zhao, XioaDong; Shao, Zhifeng; Li, Xiaowei; Wu, XinYan; Tang, Daonian; Liu, Yazhi; (28 pag.)CN103804447; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia