As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, molecular formula is C12H12Cl2N3OP, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1197953-49-3
Compound c24-10 (200 mg, 0.58 mmol) was dissolved in 18 ml of ethylene glycol monobutyl ether, then compound b3-1 (237 mg, 0.75 mmol) was added with stirring at room temperature.0.36 ml of a hydrochloric acid solution in ethanol(5.6 M) was reacted at 120 C overnight.TLC showed that the reaction was completed, diluted with water and ethyl acetate.Concentrated to give crude product by column chromatography to give c-24,20mg.
With the rapid development of chemical substances, we look forward to future research findings about 1197953-49-3.
Reference:
Patent; Zhejiang Tongyuankang Pharmaceutical Co., Ltd.; Wu Yusheng; Zhi Wubin; Wang Xin; Wu Shiyong; Li Jingya; Guo Ruiyun; Zheng Maolin; Liang Apeng; Wang Guohui; Chen Mingtao; Ma Jie; Niu Chengshan; (65 pag.)CN108689994; (2018); A;,
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