Synthetic Route of 3747-74-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3747-74-8 as follows.
General procedure: To a mixture of 3-bromo-4-nitrophenol (26, 4.91 g, 22.5 mmol), 2-(chloromethyl)quinoline hydrochloride (5.79 g, 27.0 mmol) and potassium iodide (374 mg, 2.25 mmol) in DMF (50 mL) was added K2CO3 (7.47 g, 54.1 mmol), and the mixture was stirred at 60 C for 90 min. After cooling at room temperature, the mixture was diluted with EtOAc, and washed with water and brine. The organic layer was dried over Na2SO4 and concentrated in vacuo. The residue was washed with EtOAc-hexane to give 27 (6.89 g, 85%) as a pale yellow solid.
According to the analysis of related databases, 3747-74-8, the application of this compound in the production field has become more and more popular.