In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4491-33-2, name is Ethyl quinoline-2-carboxylate belongs to quinolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Formula: C12H11NO2
General procedure: A 50mL Schlenk flask, equipped with a magnetic stir bar, was charged with [Ir(cod)Cl]2 (3.4 mg, 5¡Á10-3 mmol) and the selected chiral ligand (1.1¡Á10-2 mmol). Then, the mixture was conditioned by three vacuum/nitrogen cycles and the degassed solvent (8 mL) was added. The mixture with the precatalyst was stirred at room temperature for 1 h before cannula transfer into a 50 mL double-walled stainless steel autoclave containing the substrate (1 mmol) and iodine (12.7 mg, 0.05 mmol). The autoclave was purged and pressurized with molecular hydrogen and the reaction was performed at the specified temperature during 17 h. At the end of the reaction, the autoclave was cooled and depressurized. The mixture was filtered through a small pad of silica gel and analyzed by GC or NMR to determine the conversions. The enantiomeric excesses were determined by HPLC. 4.3.2 Ethyl 1,2,3,4-tetrahydroquinoline 2-carboxylate 18. HPLC: Chiralcel OJ-H Hexane/iPrOH 70/30, flow 1 mL/min, lambda=254 nm; t1 18.18min, t2 29.18 min; 1H NMR (300 MHz, CDCl3) 1.32 (3H, t, J 6.7Hz, CH3), 2.02 (1H, m, CH2), 2.33 (1H, m, CH2), 2.80 (2H, m, CH2), 4.07 (1H, m, CH), 4.27 (2H, q, J 6.7Hz, CH2), 4.44 (1H, s, NH), 6.66 (2H, m, CHar), 6.99 (2H, m, CHar); 13C NMR (75 MHz, CDCl3) 14.41, 24.66, 25.79, 53.98, 61.44, 115.03, 118.12, 120.98, 127.10, 129.17, 142.42, 173.09.
The synthetic route of 4491-33-2 has been constantly updated, and we look forward to future research findings.