The origin of a common compound about 130838-36-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,130838-36-7, 2,6-Dichloropyrimidine-4,5-diamine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.130838-36-7, name is 2,6-Dichloropyrimidine-4,5-diamine, molecular formula is C4H4Cl2N4, molecular weight is 179.0074, as common compound, the synthetic route is as follows.Quality Control of 2,6-Dichloropyrimidine-4,5-diamine

A suspension of 2,6-dichloropyrimidine-4,5-diamine (16b) (4.4 g, 24.58 mmol) in water (47 ml) was heated and the solid was dissolved. The solution was cooled to 0 C and acetic acid (94 ml) was added, followed by addition of a solution of sodium nitrite (3.05 g, 44.3 mmol) in water (47 mL) during a period of 15 mm. The reaction mixture was stirred at 0 C for another 20 mm and then was extracted with EtOAc. The organics were neutralized, dried and concentrated, the crude product was purified by column chromatography (petroleum ether/ethyl acetate: from 3:1 to 2:1) to provide the title compound (16c) (3.4 g, 72.8%) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,130838-36-7, 2,6-Dichloropyrimidine-4,5-diamine, and friends who are interested can also refer to it.

Reference:
Patent; ORIC PHARMACEUTICALS, INC.; DU, Xiaohui; EKSTEROWICZ, John; FANTIN, Valeria R.; JACKSON, Erica L.; SUN, Daqing; YE, Qiuping; MOORE, Jared; ZAVOROTINSKAYA, Tatiana; (262 pag.)WO2019/90111; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia