Adding a certain compound to certain chemical reactions, such as: 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 39906-04-2, blongs to pyrimidines compound. HPLC of Formula: C5H5Cl2N3
2-Methyl-4,6-dichloro-5-aminopyrimidine (Aldrich, 1.05 g) and ammonium hydroxide(3.0 mL, J.T. Baker, Phillipsburg, NJ, 28.0% – 30.0 %) were placed in a microwave vial. The vial was sealed and heated in a CEM microwave reactor (CEM Corporation, Matthews, NC) at120 0C and 40 Watts for 25 minutes. The reaction mixture was cooled to room temperature. This procedure was repeated a total of nine times using the following amounts of 2-methyl-4,6- dichloro-5-aminopyrimidine under the same reaction conditions:Run 2: 1.027 g. 2.5 mL ammonium hydroxide.Run 3: 1.034 g, 2.5 mL ammonium hydroxide.Run 4: 1.118 g, 2.6 mL ammonium hydroxide. Run 5 : 1.117 g, 2.5 mL ammonium hydroxide.Run 6: 1.149 g, 2.7 mL ammonium hydroxide.Run 7: 1.264 g, 2.6 mL ammonium hydroxide.Run 8: 1.106 g, 2.6 mL ammonium hydroxide.Run 9: 1.075 g, 2.7 mL ammonium hydroxide.All the runs were combined and concentrated to give 6-chloro-2-methylpyrimidine-4,5-diamin. MS (ESI pos. ion) m/z: 159. Calcd. MS: 158.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39906-04-2, its application will become more common.
Reference:
Patent; AMGEN INC.; BODE, Christiane; BOEZIO, Alessandro; CHENG, Alan, C.; CHOQUETTE, Deborah; COATS, James, R.; COPELAND, Katrina, W.; HUANG, Hongbing; LA, Daniel; LEWIS, Richard; LIAO, Hongyu; POTASHMAN, Michele; STELLWAGEN, John; YI, Shuyan; NORMAN, Mark; STEC, Markian; PETERSON, Emily, A.; GRACEFFA, Russell; WO2010/132598; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia