Reference of 579476-26-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 579476-26-9, name is 3-Pyrimidin-2-yl-benzoic acid, molecular formula is C11H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[00219] To a solution of N-(4-chlorophenyl)-5,5-difluoropiperidine-3-carboxamide (50 mg, 0.18 mmol) in THF (2 ml) was added 3-(pyrimidin-2-yl)benzoic acid (44 mg, 0.22 mmol) followed by N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (52 mg, 0.27 mmol), N,N-diisopropylethylamine (0.095 ml, 0.55 mmol), and 4- (dimethylamino)pyridine (4.4 mg, 0.036 mmol). The reaction stirred overnight at room temperature. The reaction mixture was poured into ethyl acetate and washed with saturated aqueous sodium bicarbonate solution and brine. The organic layer was dried over magnesium sulfate, filtered, and concetrated. The crude residue was purified by column chromatography eluting with 40-60% ethyl acetate in hexanes to give the title compound (75mg, 90%). ?H NMR (400 MHz, DMSO-d6, 80 C) oe 10.04, 8.90, 8.49, 8.43, 7.63, 7.56, 7.44, 7.32, 4.33, 4.20, 3.57, 3.25, 3.00, 2.96, 2.46, 2.30.
According to the analysis of related databases, 579476-26-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY; LARSEN, Scott, D.; NEUBIG, Richard; HAAK, Andrew; HUTCHINGS, Kim; RAJESWARAN, Walajapet; (156 pag.)WO2016/73847; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia