In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4359-87-9, name is 2,4,6-Trichloro-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 4359-87-9
PREPARATION 112 2-Chloro-6-morpholin-4-yl-9-(tetrahydro-2W-pyran-4-yl)-7,9-dihydro-8H-purin-8- o a) 4-(2,6-Dichloro-5-nitropyrimidin-4-yl)morpholine A solution of morpholine (362 mg, 4.16 mmol) and triethylamine (0.58 mL, 4.16 mmol) in methylene chloride (11 mL) was added dropwise to a cooled (0 C) solution of 2,4,6- trichloro-5-nitropyrimidine (950 mg, 4.16 mmol) in methylene chloride (25 mL) and the resulting mixture was stirred overnight at ambient temperature. Solvent was then evaporated and the crude was purified by flash cromatography (3:1 hexanes/ethyl acetate) to yield the title compound (780 mg, 67%) as a yellow solid. LRMS (m/z): 279 (M+1)+ 1H NMR (300 MHz, CDCI3) delta ppm 3.77 (m, 4H), 3.50 – 3.67 (m, 4H).
The synthetic route of 4359-87-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; GONZALEZ RODRIGUEZ, Jacob; GOMEZ CASTILLO, Elena; BACH TANA, Jordi; WO2011/157397; (2011); A1;,
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