Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 3680-71-5, Name is 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, molecular formula is C6H5N3O. In an article, author is Kalt, Marc-Manuel,once mentioned of 3680-71-5, Quality Control of 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one.
Palladium-catalysed synthesis of arylnaphthoquinones as antiprotozoal and antimycobacterial agents
Malaria and tuberculosis are still among the leading causes of death in low-income countries. The 1,4-naphthoquinone (NQ) scaffold can be found in a variety of anti-infective agents. Herein, we report an optimised, high yield process for the preparation of various 2-arylnaphthoquinones by a palladium-catalysed Suzuki reaction. All synthesised compounds were evaluated for their in-vitro antiprotozoal and antimycobacterial activity. Antiprotozoal activity was assessed against Plasmodium falciparum (P.f.) NF54 and Trypanosoma brucei rhodesiense (T.b.r.) STIB900, and antimycobacterial activity against Mycobacterium smegmatis (M.s.) mc(2) 155. Substitution with pyridine and pyrimidine rings significantly increased antiplasmodial potency of our compounds. The 2-aryl-NQs exhibited trypanocidal activity in the nM range with a very favourable selectivity profile. (Pseudo)halogenated aryl-NQs were found to have a pronounced effect indicating inhibition of mycobacterial efflux pumps. Cytotoxicity of all compounds towards L6 cells was evaluated and the respective selectivity indices (SI) were calculated. In addition, the physicochemical parameters of the synthesised compounds were discussed. (C) 2020 The Authors. Published by Elsevier Masson SAS.
If you¡¯re interested in learning more about 3680-71-5. The above is the message from the blog manager. Quality Control of 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia