Reference of 7226-23-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 7226-23-5, Name is 1,3-Dimethyltetrahydropyrimidin-2(1H)-one, SMILES is O=C1N(C)CCCN1C, belongs to pyrimidines compound. In a article, author is Faraji, Aram, introduce new discover of the category.
Design, synthesis and evaluation of novel thienopyrimidine-based agents bearing diaryl urea functionality as potential inhibitors of angiogenesis
Inhibition of angiogenesis is a promising strategy for the treatment of cancer. Herein, we describe the design and synthesis of thieno[2,3-d]pyrimidine-1,3,4-thiadiazole-aryl urea derivatives 11a-m to evaluate their efficacy in the chick chorioallantoic membrane (CAM) assay. Among target agents, 11i had a considerable activity against prostate cancer cell line, PC3 (IC50 = 3.6 mu M). Moreover, induction of apoptosis, good inhibitory activity against the growth of capillary blood vessels, and inhibition of VEGFR-2 phosphorylation were noticeable parameters which convinced us that 11i could be considered as a promising candidate for the discovery of novel drugs to treat tumors, particularly prostate cancer. (c) 2020 Elsevier Masson SAS. All rights reserved.
Reference of 7226-23-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 7226-23-5.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia