Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 3051-09-0, Name is Murexide, SMILES is O=C1[N-]C(/C(C(N1)=O)=N/C(C(N2)=O)C(NC2=O)=O)=O.[NH4+], belongs to pyrimidines compound. In a document, author is Kumagai, Shinji, introduce the new discover, HPLC of Formula: C8H8N6O6.
Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides
We recently designed guanidine-bridged nucleic acids (GuNA), and GuNA bearing a thymine (T) nucleobase was synthesized and successfully incorporated into oligonucleotides. The GuNA-T-modified oligonucleotides possessed high duplex-forming ability towards their complementary single-stranded RNAs and were highly stable against 3 ‘ -exonuclease. Therefore, GuNA is a promissing artificial nucleic acid for therapeutic antisense oligonucleotides. We herein report the facile synthesis of GuNA phosphoramidites bearing adenine (A), guanine (G), and 5-methylcytosine (C-m) nucleobases and a robust method for the preparation of GuNA-modified oligonucleotides, even with sequences having acid-sensitive purine nucleobases. Oligonucleotides modified with GuNA-A, -G, or -C-m possessed high duplex-forming ability, similar to those modified with GuNA-T. Moreover, some of the GuNA-modified oligonucleotides were revealed to have high base discriminating ability compared with that of their natural counterparts. GuNA nucleosides exhibited no genotoxicity in bacterial reverse mutation assays. Thus, all GuNAs (GuNA-T, -A, -G, and -C-m) are now available to be examined in therapeutic applications.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 3051-09-0 is helpful to your research. HPLC of Formula: C8H8N6O6.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia