Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 4983-28-2, Name is 2-Chloro-5-hydroxypyrimidine, molecular formula is C4H3ClN2O, belongs to pyrimidines compound, is a common compound. In a patnet, author is You, Rong, once mentioned the new application about 4983-28-2, Product Details of 4983-28-2.
Probing cell metabolism on insulin like growth factor(IGF)-1/tumor necrosis factor(TNF)-alpha and chargeable polymers co-immobilized conjugates
Cell culturing on different synthetic biomaterials would reprogram cell metabolism for adaption to their living conditions because such alterations in cell metabolism were necessary for cellular functions on them. Here we used metabolomics to uncover metabolic changes when liver cells were cultured on insulin-like growth factor (IGF)/tumor necrosis factor-alpha (TNF-alpha) and chargeable polymers co-modified biomaterials with the aim to explain their modulating effects on cell metabolism. The results showed that cell metabolism on IGF-1/TNF-alpha co-immobilized conjugates was significantly regulated according to their scatterings on the score plot of principal component analysis. Specifically, cell metabolisms were reprogrammed to the higher level of pyrimidine metabolism, beta-alanine metabolism, and pantothenate and CoA biosynthesis, and the lower level of methionine salvage pathway in order to promote cell growth on IGF/TNF-alpha co-modified surface. Furthermore, cell senescence on PSt-PAAm-IGF/TNF-alpha surface was delayed through the regulation of branch amino acid metabolism and AMPK signal pathway. The research showed that metabolomics had great potential to uncover the molecular interaction between biomaterials and seeded cells, and provide the insights about cell metabolic reprogramming on IGF/TNF-alpha co-modified conjugates for cell growth.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia