Application of 53554-29-3, Adding some certain compound to certain chemical reactions, such as: 53554-29-3, name is Ethyl 2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxylate,molecular formula is C8H10N2O3S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 53554-29-3.
Ethyl 4-hydroxy-2-(methylthio)pyrimidine-5-carboxylate (6; 10 g;46.7 mmol) was dissolved in a mixture of dioxan and chloroform (1:1;262 mL). Reaction mixture was cooled up to -2C, treated with m-CPBA (60%; 20.14 g, 70.0 mmol) and stirred for 50 min at 0 C.Reaction mixture was quenched by 10% aq. sodium metabisulfite(262 mL), extracted with chloroform and washed with aq. 10% sodiumbicarbonate. The organic layer was dried over sodium sulfate (40 g) andthe solvent was evaporated under reduced pressure to obtain ethyl 4-hydroxy-2-(methylsulfinyl)pyrimidine-5-carboxylate as a white solid.(8.6 g, 80%), which was further used in the next step without purification.To the mixture of ethyl 4-hydroxy-2-(methylsulfinyl)pyrimidine-5-carboxylate (8.6 g; 37.4 mmol) and PTSA (7.82 g; 41.1 mmol), dissolvedin NMP (80 mL) was added 4-(methylsulfonyl)aniline (6.99 g;37.4 mmol), at RT. The reaction mixture was heated at 100-110 C for1-2 h. After completion of reaction, the mixture was diluted with waterand the compound was extracted in EtOAc. Organic layer was driedover sodium sulfate, filtered and concentrated under vacuum to affordthe crude product. Crude product was purified by flash chromatographyover silica gel (100-200 mesh) with 2% MeOH/CHCl3 to get the ethyl4-hydroxy-2-((4-((methylsulfonyl) oxy)phenyl)amino) pyrimidine-5-carboxylate (7) (9.9 g, 75%). 1H NMR (DMSO-d6, 400 MHz) delta ppm 1.26(t, J = 7.0 Hz, 3H), 3.48 (s, 3H), 4.20 (q, J = 6.8 Hz, 2H), 6.57 (d,J = 9.2 Hz, 2H), 7.34 (d, J = 8.8 Hz, 2H), 8.49 (s, 1H), 9.75 (s, 1H),11.25 (s, 1H): ESI-MS: m/z Calcd for C14H16N3O6S [M+1]+ 354.35,found 354.58.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 53554-29-3, Ethyl 2-(methylthio)-6-oxo-1,6-dihydropyrimidine-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Argade, Anil; Bahekar, Rajesh; Bandyopadhyay, Debdutta; Chatterjee, Abhijit; Desai, Jigar; Desai, Ranjit C.; Ghoshdastidar, Krishnarup; Gite, Archana; Gite, Sanjay; Kumar, Jeevan; Mahapatra, Jogeswar; Panchal, Nandini; Patel, Bhaumin; Patel, Dipam; Patel, Harilal; Patel, Hoshang; S, Sachchidanand; Soman, Shubhangi; Sundar, Rajesh; Bioorganic Chemistry; vol. 99; (2020);,
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