Synthetic Route of 1032452-86-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. A new synthetic method of this compound is introduced below.
GB012 (0.5g, 2.06mmol) and 2-methoxy-5-nitroaniline (0.347g, 2.06mmol) were dissolved in 2-pentanol (20mL), p-toluenesulfonic acid monohydrate ( 0.471g, 2.5mmol), then heated to 105 , reacted for 2.5 hours, and finally cooled to room temperature. It was suction filtered, and the filter cake was washed with 2-pentanol (5 mL) and dried to obtain GB104 (0.37 g).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1032452-86-0, its application will become more common.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Guo Dexiang; Yan Ziqin; (89 pag.)CN108069939; (2020); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia