Application of 720-01-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 720-01-4, name is Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate, molecular formula is C8H6ClF3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of P(t-Bu)3 (0.32 g, 1.57 mmol) and Tris(dibenzylideneacetone)dipalladium(0) (Pd2(dba)3) (0.72 g, 0.78 mmol), in 10 ml of THF, stirred at room temperature for 30 min, the dark red heterogeneous solution Pd(P(t-Bu)3)2 formed. Then KF (2.74 g, 47.24 mmol), and 3,4-dimethoxyphenylboronicacid (2.15 g, 11.80 mmol) in dry THF (50ml) was added. Finally ethyl-4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate (2g, 7.87 mmol), was added under N2 atmosphere. The reaction mixture was heated to 65C for 14 h. TLC showed the completion of the reaction. Then the mixture was cooled and concentrated under vacuo to get crude residue, which was purified by column chromatography over silica gel (Ethylacetate/ Hexane, 1:3) to afford title product as an off-white solid in 74% yield. ESI-MS: 357 (M+1).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 720-01-4, Ethyl 4-chloro-2-trifluoromethylpyrimidine-5-carboxylate.
Reference:
Article; Purushothaman, Baskaran; Arumugam, Parthasarathy; Kulsi, Goutam; Song, Joon Myong; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 673 – 690;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia