Adding a certain compound to certain chemical reactions, such as: 73418-88-9, Methyl 5-aminopyrimidine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Methyl 5-aminopyrimidine-2-carboxylate, blongs to pyrimidines compound. Application In Synthesis of Methyl 5-aminopyrimidine-2-carboxylate
Methyl 5-aminopyrimidine-2-carboxylate (0.065 g, 0.425 mmol) and pyridine (0.172 mL, 2.123 mmol) were dissolved in DCM (2 mL). To this solution was added Intermediate I-141A (0.072 g, 0.212 mmol) as a solution in DCM (1 mL). The reactionmixture was allowed to stir for lh. The reaction mixture was concentrated under reducedpressure. Purified on ISCO using 0-100% EtOAc in hexanes to yield Intermediate 1-141(0.066 g, 0.145 mmol, 68.2 % yield) as a white solid. ?H NMR (400MHz, CDC13) 9.04(s, 2H), 7.87 (d, J=9.7 Hz, 1H), 6.94 (s, 1H), 5.56 (dd, J=6.5, 2.8 Hz, 1H), 5.38-5.17 (m,1H), 4.09 (s, 3H), 1.47 (d, J=6.4 Hz, 6H). LC-MS: method H, RT = 0.93 mm, MS (ESI)m/z: 456.0 (M+H)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,73418-88-9, Methyl 5-aminopyrimidine-2-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHANG, Xiaojun; PRIESTLEY, Eldon Scott; BATES, J. Alex; HALPERN, Oz Scott; REZNIK, Samuel Kaye; RICHTER, Jeremy M.; (1137 pag.)WO2018/13774; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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