Application of 330786-24-8 ,Some common heterocyclic compound, 330786-24-8, molecular formula is C17H13N5O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (120.00 mg, 395.62 mumol) was weighed in a single-mouth flask and anhydrous tetrahydrofuran (10 ml) was added. Triphenylphosphine (311.30 mg, 1.19 mmol), 2-fluoroethanol (25.34 mg, 395.62 mumol) and diethyl azodicarboxylate (239.99 mg, 1.19 mmol) were added under argon atmosphere at room temperature overnight. TLC monitoring The reaction is complete. The reaction solution was concentrated and column chromatography gave BTK-8 78.00 mg, yield 56.43%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 330786-24-8, 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shanghai Institute of Technology; Yao Zhiyi; Yang Yan; Xia Xiaoming; Xue Nannan; Shu Qisheng; Wang Qingxuan; Wang Dongsheng; (7 pag.)CN107827892; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia