Application of 56621-89-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.56621-89-7, name is 5-Amino-2-methoxypyrimidine, molecular formula is C5H7N3O, molecular weight is 125.1286, as common compound, the synthetic route is as follows.
Step 1. l-(4-Bromophenyl)-N-(2-methoxypyrimidin-5-yl)cyclobutane-l- carboxamide: Into a 200 mL round bottom flask equipped with a magnetic stir bar and under N2 was added 2-methoxypyrimidin-5-amine (1.23 g, 9.80 mmol) and l-(4-bromophenyl)cyclo- butanecarboxylic acid (2 g, 7.84 mmol). The solids were dissolved in EtOAc (20 mL) and treated with pyridine (1.24 g, 15.68 mmol, 1.27 mL) followed by propylphosphonic anhydride (7.48 g, 1 1.76 mmol, 6.99 mL, 50% purity) in EtOAc. The yellow-orange solution was stirred at 24 C for 5 hr, the reaction was worked up by adding HC1 ( 1M, 20 mL). The EtOAc layer was concentrated and purified by column chromatography eluting with 10% to 100 % (0296) EtOAc/hexanes gradient over 10 min. The desired fractions were combined, concentrated and further dried under high vacuum O/N, yielding a white solid (2 g). LCMS (ESI+) m/z = 362,364 (M+l, M+3).
The chemical industry reduces the impact on the environment during synthesis 56621-89-7, I believe this compound will play a more active role in future production and life.
Reference:
Patent; TEMPEST THERAPEUTICS, INC.; POWELL, David Andrew; ROPPE, Jeffrey Roger; SEIDERS, Thomas Jon; DING, Jinyue; SHENG, Tao; JACINTHO, Jason Duarte; (65 pag.)WO2019/79614; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
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