Synthetic Route of 156-81-0 , The common heterocyclic compound, 156-81-0, name is Pyrimidine-2,4-diamine, molecular formula is C4H6N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-Bromo-l-(3-fluorophenyl)ethanone (10.9 g, 50 mmol) was added to a solution of 2,4- diaminopyrimidine (3.70 g, 34 mmol) in acetone (185 ml), and the mixture was heated to reflux for 6 h. The cooled suspension was filtered and the precipitate was washed with acetone (50 ml). The solid was re-suspended in water (35 ml) and NH40Haq. (25%, 50 ml), then it was collected over a glass fiber paper and the filtrate was washed with Iota?0 (75 ml). After drying under vacuum, the product was obtained (5.56 g, 72%) as a yellow solid.MS (m/z) = 229.1 [M+H+].
The synthetic route of 156-81-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALVAREZ SANCHEZ, Ruben; BLEICHER, Konrad; FLOHR, Alexander; GOBBI, Luca; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; KUHN, Bernd; PETERS, Jens-Uwe; RUDOLPH, Markus; WO2011/117264; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
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