Reference of 63558-65-6, Adding some certain compound to certain chemical reactions, such as: 63558-65-6, name is 4-Chloro-5-iodopyrimidine,molecular formula is C4H2ClIN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63558-65-6.
Preparation 57A: 5-Iodo-4-(2H-l,2, -triazol-2-yl)pyrimidine[00244] To a solution of lH-l,2,3-triazole (63.2 mg, 0.915 mmol) in THF (Volume: 241 1 ??), was added portion wise at 0 C, NaH (39.9 mg, 0.998 mmol). The reaction mixture was stirred at that temperature for 30 min, then 4-chloro-5-iodopyrimidine (200 mg, 0.832 mmol) was added. The reaction mixture was allowed to warm to room temperature. To this solution was added saturated aqueous NH4C1 and the mixture was allowed to stir for 5 min at which time it was diluted with ethyl acetate and extracted 2X. The combined organics were washed with brine IX. The organics were dried overNa2S04, filtered and concentrated in vacuo to afford the title compound (90 mg, 40%).
According to the analysis of related databases, 63558-65-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BALOG, James Aaron; HUANG, Audris; VELAPARTHI, Upender; LIU, Peiying; WO2013/49263; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia