Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 302964-08-5, name is 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide. A new synthetic method of this compound is introduced below., Recommanded Product: 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
Intermediate 3 (5 g, 1 equivalent) was added to dimethyl sulfoxide (DMSO) (13 volumes) followed by addition of HEP (3 molar equivalents). The reaction mixture was maintained between 25-300C for 15-24 hours. Water (20 volumes) was added and maintained at this temperature for 45 minutes. The resultant solid was filtered and washed with water and dried in a vacuum tray drier at 500C for 8-12 hours. The isolated solid weighed 4.5 g. XRPD characterisation showed the isolated product to be crystalline dasatinib monohydrate substantially matching the XRP diffractogram according to Figure 1. Chemical Purity >; 97% as measured by HPLC.
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Reference:
Patent; GENERICS [UK] LIMITED; MYLAN INDIA PRIVATE LIMITED; GORE, Vinayak Govind; PATKAR, Laxmikant; BAGUL, Amit; VIJAYKAR, Priyesh Surendra; EDAKE, Mahesh; WO2010/139980; (2010); A1;,
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