As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 3977-29-5, name is 2-Amino-6-methylpyrimidin-4(1H)-one, molecular formula is C5H7N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C5H7N3O
Methyl isocytosine (2.0 g) was added to 4,4′-methylenebis (phenylisocyanate) (MDI, 8.1 g) dissolved in 35 mL THF and subsequently stirred at an oil bath temperature of 75 [C] under an argon atmosphere. After 4 hours, 40 [ML] chloroform was added and the white precipitate was separated by filtration and washed with chloroform. 1H NMR (400 MHz, DMSO-d6): 8 10.0 (1H), 8.6 (1H), 7.4 [(5H),] 7.2 (4H), 5.8 (1H), 3.8 (2H), 2.1 (3H). FT-IR (neat): v [(CRI-1)] 3329,2954, 2257,1699, 1658,1578, [1508,] 1244.
With the rapid development of chemical substances, we look forward to future research findings about 3977-29-5.
Reference:
Patent; SUPRAPOLIX, B.V.; WO2004/16598; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia