Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 123148-78-7, name is 4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 123148-78-7
DMF (66mL) was added to a mixture of compound 12 1 (2.00g, 7.15mmol) and 59 sodium hydride (243mg, 10.1mmol) under nitrogen atmosphere. The reaction mixture was cooled to 0C and stirred for 30min. 60 2-(Trimethylsilyl)-ethoxymethyl chloride (1.70mL, 9.58mmol) was added dropwise over 45min and stirred at 22C for 1.5h. 61 Water (150mL) and 62 EtOAc (150mL) was added to the reaction mixture, the phases were separated, and the water phase was extracted with more EtOAc (2¡Á150mL). The combined organic phases were dried over Na2SO4, filtered, and concentrated in vacuo. The product was purified by silica-gel column chromatography (n-pentane/EtOAc, 1/1, Rf=0.78) to give 2.74g (10.0mmol, 86%) of a pale yellow 63 powder; mp. 98-104C; 1H NMR (400MHz, DMSO-d6): 8.69 (s, 1H), 8.13 (s, 1H), 5.60 (s, 2H), 3.51 (t, J=8.1, 2H), 0.82 (t, J=8.1, 2H),-0.10 (s, 9H). The spectroscopic data corresponded with that reported previously [40].
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 123148-78-7, 4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine.
Reference:
Article; Reiers¡ãlmoen, Ann Christin; Han, Jin; Sundby, Eirik; Hoff, Bard Helge; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 562 – 578;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia