Application of 1004-39-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol, molecular formula is C4H6N4S, molecular weight is 142.18, as common compound, the synthetic route is as follows.
General procedure: DBU (0.33 ml, 2.2 mmol) was added dropwise at roomtemperature to a stirred suspension of the respective thiol2a-n (2.2 mmol) in anhydrous MeCN (4 ml). The obtainedmixture was stirred for 15 min and then furoxan 1d (0.34 g,1.0 mmol) was added. The reaction mixture was furtherstirred for 48-120 h until complete conversion of thestarting furoxan 1d (control by TLC, eluent CHCl3). Thereaction mixture was then diluted with H2O (20 ml). The precipitate formed was filtered off, carefully washed withwater, 0.75 N NaOH, then again with water, acetonitrile(~1 ml), and air-dried.
The chemical industry reduces the impact on the environment during synthesis 1004-39-3, I believe this compound will play a more active role in future production and life.
Reference:
Article; Fershtat, Leonid L.; Epishina, Margarita A.; Kulikov, Alexander S.; Struchkova, Marina I.; Makhova, Nina N.; Chemistry of Heterocyclic Compounds; vol. 51; 2; (2015); p. 176 – 186; Khim. Geterotsikl. Soedin.; vol. 51; 2; (2015); p. 176 – 186,11;,
Pyrimidine | C4H4N2 – PubChem,
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