Application of 147118-40-9, Adding some certain compound to certain chemical reactions, such as: 147118-40-9, name is Rosuvastatin methyl ester,molecular formula is C23H30FN3O6S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 147118-40-9.
EXAMPLE 2; PREPARATION OF N,N’-DIBENZYLETHYLENEDIAMINEROSUVASTATIN SALT; Rosuvastatin methyl ester was (1 g) was dissolved in ethanol (15 ml) at 25-300C and cooled to 0-50C and treated with aqueous sodium hydroxide (0.1 N, 20 ml) at 0-50C. The temperature of the reaction mass was raised to 25-300C and stirred for 1 hr. Ethanol was evaporated from the reaction mass under reduced pressure at 40-450C and the resulting aqueous layer was diluted further with 15 ml of DM water. This aqueous layer containing rosuvastatin was washed with 30percent v/v ethyl acetate/toluene (50 ml) at 25-300C and treated with aqueous solution of N,N’- dibenzylethylenediamine diacetate (0.9 g in 5 ml). The resulting suspension was stirred for 1 hr for complete precipitation and the precipitated product was filtered, slurry washed with ethyl acetate (20 ml) and dried under vacuum at 40-450C. Dry wt. 0.68 g; Chromatographic purity (HPLC): 99.28percent, Anti isomer: 0.59percent.; EXAMPLE 3PREPARATION OF N,N’-DIBENZYLETHYLENEDIAMINEROSUVASTATINA solution of rosuvastatin methyl ester (5 g) in ethanol (70 ml) was treated with aqueous sodium hydroxide (0.1N, 88 ml) at 0-50C and the temperature of the reaction was raised to 300C and stirred for 1 h. Ethanol from the reaction mass was evaporated at 40-450C. This aqueous layer was washed with 30 v/v ethyl acetate/toluene (3 x 25 ml) and treated with an aqueous solution of N,N’-dibenzylethylenediamine diacetate(1.8 g in 10 ml water). The resulting mass was further stirred for a period of 2 h, filtered, slurry washed with ethyl acetate (30 ml) and dried under vacuum at 40-450C.
According to the analysis of related databases, 147118-40-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AUROBINDO PHARMA LIMITED; WO2008/38132; (2008); A1;,
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