Application of 90905-33-2 ,Some common heterocyclic compound, 90905-33-2, molecular formula is C6H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 4-6 (5.5 g, 16.2 mmol), 5-formyl-2-methylpyrimidine (4-6a, 1.8g, 14.7 mmol; for preparation, see J. Heterocyclic Chem., 28, 1281 (1991)) in 40 mL DMF wasadded K2C03 (4.07 g, 32 mmol). The mixture was stirred at ambient temperature for 15 hr, and concentrated to a paste. The residue was diluted with water, extracted with ethyl acetate, and dried over magnesium sulfate. Following concentration, the residue was chromatographed on silica gel (70 chloroform / 25 ethyl acetate / 5 methanol) to give 4-7 as a white solid. Rf= 0.20 (silica, 70 chloroform / 20 ethyl acetate / 10 methanol).?H NIVIR (400 MFIz, CDC13) oe 8. 80(s, 2H), 7.44 (d, 1H, J16Hz), 7.05 (d, 1H, J=7Hz), 6.81 (d,1H, J16Hz), 6.35 (d, 1H, J=7Hz), 4.72 (br s, 1H), 3.39 (m, 2H), 2.69 (s, 3H), 2.64 (m, 4H), 2.58(m, 2H), 1.91 (m, 2H), 1.74 (m, 4H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,90905-33-2, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; COX, Jason, M.; MA, Lijun; ZHOU, Xiaoyan; HAIMBACH, Robin, E.; COLEMAN, Paul, J.; ZHOU, Haihong; KELLEY, David, E.; STOCH, Selwyn Aubrey; DUONG, Le, T.; HOEK, Maarten; (68 pag.)WO2016/154369; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
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